Rosso N, Marin V, Giordani A, Persiani S, Sala F, Cavicchioli L, Rovati LC, Tiribelli C. The pros and the cons for the use of Silybin-rich oral formulations in treatment of liver damage (NAFLD in particular). There are some possible milk thistle drug interactions to be aware of if you are considering taking this supplement. Below is a short list of some other medications that are processed through the CYP3A4 enzyme. Blood pressure is defined as the pressure pushed against artery walls as a result of the heart pumping blood. No: No there is not. It can also cause problems if you're taking antipsychotic drugs, antianxiety drugs, certain cancer medications, or blood thinners. According to the DNA sampling that has been done, all people with blue eyes and blonde hair (such As we might expect, part of the problem with the distribution of melanin has to do with liver enzymes and imbalance. There’s not currently enough evidence available to assess whether milk thistle may interact negatively with prescription medications. Milk thistle might help the body break down estrogen pills to get rid of them. Milk thistle supplementation helps the liver to clear out hormones, drugs, alcohol, environmental toxins and other harmful agents. Studies suggesting milk thistle interferes with some drugs have delivered inconsistent results. This may result in significant changes to the normal effects of the drugs, as well as the prevalence and severity of possible side effects. A US doctor answered Learn more. It is likely safe even at high doses over long time spans (up to 44 months). Metronidazole (Flagyl). The therapeutic potential of milk thistle in diabetes. Does Milk Thistle Interfere With Iron Elevated Family Medicine Enzymes Pkpi System. Does Milk Thistle Interfere With Chemotherapy Without Recovery Alcohol an abnormal growth of cells and tissues is called a tumour. Caution is recommended if using milk thistle in conjunction with diabetic medications, as blood glucose levels may drop below recommended levels. 2015 Jul 29. 2015 Feb 15;22(2):290-6. Post-White J1, Ladas EJ, Kelly KM. What does this have to do with HIV? This list is not exhaustive: heart drugs -- Tambocor (flecainide), Rythmol (propafenone), anti-seizure drugs -- carbamazepine (Tegretol), antidepressants -- St. John's wort, Zyban/Wellbutrin (bupropion), Paxil (paroxetine), Prozac (fluoxetine), Luvox (fluvoxetine) Serzone (nefazodone), Zoloft (sertraline), Effexor (venlafaxine), antihistamines -- Hismanal (astemizole), Seldane (terfenadine), antifungals -- itraconazole (Sporanox), Ketoconazole (Nizoral), gastrointestinal motility agents -- Prepulsid (Cisapride), ergot drugs -- Ergonovine, Ergomar (ergotamine), anti-psychotics -- Clozaril (clozapine), Orap (pimozide), sedatives/sleeping pills -- Ambien (zolpidem), Halcion (triazolam), Versed (midazolam), lipid-lowering drugs (statins) -- Lescol (fluvastatin), Mevacor (lovastatin), Pravachol (pravastatin) and Zocor (simvastatin), Baycol (cerivastatin), transplant drugs -- cyclosporine (Neoral, Sandimmune), ProGraf (tacrolimus). Researchers at the University of Pittsburgh have suspected that milk thistle can slow down or reduce the activity of enzymes in the liver. Do not mix S. marianum with the following herbs without first consulting with your your primary healthcare provider: The United States Food and Drug Administration does not regulate the use of herbal supplements and there are no available guarantees concerning the strength or safety of these medicinal agents. If possible, wait four hours after you take your meds until you take the milk thistle. A number of serious side effects are possible and a physician’s approval should be sought prior to combining herbal supplements. Mariendistel” and milk thistle from Naka is a high potency supplement ideal for detoxification weight milk thistle extract weight loss inflamed tylenol loss and digestive support. Milk thistle also has the potential to lower levels of the following drugs: anti-parasite drugs -- Mepron (atovaquone), sedatives/sleeping pills -- Ativan (lorazepam). PMC. There are no interactions or contra-indications with medication listed for milk thistle extract. Your email address will not be published. Because of this enzyme reduction, certain medications might take longer to break down, which means that they’ll be in the system longer than normal. Some antidepressants/sedatives MAY interfere with skin testing and should be brought to the attention of your Allergist. Dandelion may interact with other medication, even though it is a natural herbal supplement. i ntake is a predictor of LDL “You have to have very definite evidence that the person is going to stop drinking. Some cancer drugs. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Save my name, email, and website in this browser for the next time I comment. However, University of Pittsburgh researchers published their findings in 2000 that silymarin inhibits cytochrome P-450. Brantley, Scott J. et al. Compounds found in milk thistle -- sylibin, sylimarin -- act as antioxidants and also stimulate the repair of the liver. The Journal of Pharmacology and Experimental Therapeutics 332.3 (2010): 1081–1087. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. may cause a number of effects on the human body, A number of serious side effects are possible. … A 45-year-old member asked: Is there a drug interactions between milk thistle and pomegranate? Ed. Silybum marianum may interact with other herbal remedies and dietary supplements. The antioxidant potential of silymarin is believed to be at least ten times that of vitamin E. It has also been observed to significantly increase the availability of superoxide dismutase (SOD), one of the body’s most important antioxidants. 2007 Jun; 6(2):104-9. Your email address will not be published. By affecting the cytochrome p450 liver enzyme system, this supplement may alter drug metabolism in the liver. Surinder K. Batra. 2014 Summer;11(2):167-74. Antiplatelet and anticoagulant drugs (blood thinners). However, little conclusive information is available about milk thistle interactions. Milk thistle is generally well tolerated by the majority of users. According to research, the reason behind this interference is that the same liver enzymes digest both milk thistle and the medications mentioned above. Although serious side effects are rare, the use of milk thistle with interacting drugs or supplements can increase the risk of adverse effects. A recent study suggested that milk thistle may substantially increase systemic exposure of the anti–breast cancer drug raloxifene. Milk thistle is known to promote lactation and is commonly classified as a galactogogue. As a result, the levels of these drugs may become elevated or diminished in the blood. Milk thistle also has the potential to lower levels of the following drugs: anti-parasite drugs - Mepron (atovaquone) sedatives/sleeping pills - Ativan (lorazepam) … Metronidazole (Flagyl). Early research suggests that milk thistle may decrease the activity of certain liver enzymes. 10 Aug. 2015. Milk Thistle Drug Interactions, Dangers and Contraindications Closely monitor your blood sugar levels. Silymarin is a versatile substance that may cause a number of effects on the human body. To date, milk thistle has been observed to exhibit anti-inflammatory, antioxidant, anticancer, anti-diabetic, cardioprotective, hepatoprotective and renoprotective actions. No serious or permanent side effects have been attributed to this herbal extract. 3. 1. Dandelion interacts with medicines that treat diabetes or control blood sugar levels. Milk thistle should not be used in place of medication prescribed for you by your doctor. Answer: Milk does interfere with drug absorption but not due to the high content of saturated fats. Integr Cancer Ther. Anti-anxiety drugs. Milk thistle might decrease hormones in the body. Contemporary uses of milk thistle have expanded beyond that of traditional practice. you might ask. Deep, Gagan et al. (Meaning even low-fat milk should be avoided for such drugs) 1. What medications does milk thistle interfere with? Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Allergy drugs -- such as fexofenadine (Allegra) Drugs for high cholesterol -- such as lovastatin (Mevacor, Altocor) Serious reactions are possible. If you are considering milk thistle supplementation, prescription medication dosages may need to be altered. Neoplasma. Studies have shown a decrease in blood sugar levels and an improvement in cholesterol in people with type 2 diabetes. Levels of these medications may increase if taken by people who are also using milk thistle. This research also shows the need to conduct further research on herb-drug interactions on liver cells as well as in people. Possible interactions include:Cytochrome P450 2C9 (CYP2C9) substrates. The seeds of S. marianum contain the phytochemicals (plant nutrients) believed responsible for the majority of the plant’s beneficial properties. While it is considered to be relatively safe to use, it may interact with some pharmaceutical drugs and supplements. This cannot be stressed enough. Some lipid-lowering drugs like Mevacor, Lescol, Zocor, Pravachol, and Baycol are affected by the intake of milk thistle extract. Diabetes is a serious condition. Silymarin also encourages protein synthesis in the liver, and suppresses leukotriene production. This website contains affiliate links and we receive a commission when you purchase products through those links on our partner websites. Milk thistle also has the potential to lower levels of the following drugs: anti-parasite drugs -- Mepron (atovaquone) sedatives/sleeping pills -- Ativan (lorazepam) Taking milk thistle might affect this enzyme and drugs it processes, such as diazepam (Valium), warfarin (Coumadin, Jantoven) and others.Diabetes medications. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Allergy drugs. Milk thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures. Web. Many medications taken by people with HIV/AIDS (PHAs) -- such as protease inhibitors and non-nukes -- are processed by this liver enzyme. Ebrahimpour Koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-Jafarabadi M. Effects of Silybum marianum (L.) Gaertn. In humans, glutathione levels have been increased by roughly 35 percent. does milk thistle interfere with any prescription drugs. PMC. World J Hepatol. Tricyclic Antidepressants (TCAs): Elavil, Limbitrol (Amitripyline), Doxepin, Tofranil (Imipramine), Vivactil For centuries it was primarily used for the prevention and treatment of conditions related to the liver and/or gallbladder. 2015 Jun;41(6):540-6. This can affect the way that certain drugs are metabolized by the body. Milk thistle may interfere with some allergy drugs, high cholesterol medication, and anti-anxiety drugs. However, there is a chance that silibinin, a component of silymarin, may interfere with certain drugs such as oral contraceptives (7). A liver biopsy in 2002 was consistent Does Milk Thistle Interfere With Xanax Vicodin Hurts with chronic active hepatitis (Modified hepatitis activity index: 8/18 fiosis on trichrome stain: 1/6). Although it is a dietary supplement, milk thistle can theoretically interact with medications. Cytochrome P450 2C9 (CYP2C9) substrates. Well, enzymes in the liver break down many of the substances that we eat and drink, including medications. Such studies may find combinations of herbs and drugs that can be safely used together. Advances in the use of milk thistle (Silybum marianum). Drug Interaction Warnings: Other milk thistle drug interactions are possible when the supplement is used in combination with medications that target blood health, lactation, skin health, heart health, stomach/intestinal health, the effects of alcohol consumption, cholesterol control, fertility, hormone balancing, p-glycoprotein modulation, anxiety and/or cancer management. So yes to taking milk thistle and synthroid or levy, but try to space them out, and not take them together. © 2021 Remedy Health Media, LLC ALL RIGHTS RESERVED, https://www.thebodypro.com/article/warning-milk-thistle-drug-interactions, Visit TheBody (Our HIV Community Resource), Canadian AIDS Treatment Information Exchange. Milk thistle interactions can occur when taken with supplements or herbs that affect blood sugar, liver enzymes and hormone balance. Milk thistle (Silybum marianum) is a medicinal plant that has been used for more than 2,000 years in traditional herbal medicine. Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. The most common of these secondary iron overload states are … Researchers also have found that milk thistle improved insulin resistance, a key characteristic of type 2 diabetes. Consult with your doctor before beginning supplementation to ensure safe use. Milk thistle can increase the speed at which a medication passes through the body and can interact with some forms of medication although this is dose dependant and for some people, a smaller dose is both more effective and safer than a larger one.

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