. Acetylsalicylic acid – mechanism of action 15. . We can custom-write anything as well! Salicylic acid is composed of a benzene ring and two radicals, one hydroxyl and one carboxyl. The main mechanism of action is … The main interface in the group of antiplatelet agents passes along the point of their influence on the formed elements of the blood. There are platelet (Heparin, Aspirin, Dipyridamole) and erythrocyte (Pentoxifylline (contraindicated in patients after a heart attack), Reopoliglyukin) drugs. This action is believed to occur at the anterior (frontal) hypothalamus, a portion of the brain that regulates such functions as heart rate and body temperature. See also Analgesia; Anti-inflammatory agents; Anticoagulants. . Half-life: Low dose, 2-3 hr; higher dose, 15-30 hr . The drug is produced in the form of tablets, which include the main active ingredient acetylsalicylic acid in an amount of 500 mg. As additional components are available: Potato starch. Acetylsalicylic acid (ASA; Aspirin) is one of the first agents, which its antiglycation effect was witnessed. Stay up-to-date with the latest from DrugBank! Thank you for subscribing! Acetylsalicylic acid is one of the most used analgesics to treat an acute migraine attack. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP … This experiment was carried out to see how the hydroxyl group on the benzene ring in salicylic acid reacts with acetic anhydride to form an ester, and to make aspirin. These agents reduce the signs and symptoms of inflammation and exhibit a broad range of pharmacologic activities, including analgesic, antipyretic, and antiplatelet properties. Molecular formula of acetylsalicylic acid (aspirin) = C 9 H 8 O 4. Lemon acid. Close Print this page × Export File: RIS (for EndNote, Reference Manager, ProCite) BibTeX. Dar pentru a face acest lucru pe stomacul gol nu este recomandat, deoarece ingredientul activ al medicamentului irită mucoasa, care poate provoca o agravare a ulcerului peptic. Terms of Use. Molecular weight of acetyl salicylic acid (aspirin) = 180 g/mole. Aspirin (acetylsalicylic acid) is the best-known salicylate and belongs to the non steroid anti-inflammatory drug class. Next to the inhibitory effects on peripheral prostaglandin synthesis, central mechanisms of action have also been discussed. 7.6 Acetylsalicylic Acid 8 USE IN SPECIFIC POPULATIONS 8.1 Pregnancy 8.2 Lactation 8.4 Pediatric Use 8.5 Geriatric Use 8.6 Use in Renal Impairment 8.7 Use in Hepatic Impairment 10 OVERDOSAGE 11 DESCRIPTION 12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action 12.2 Pharmacodynamics 12.3 Pharmacokinetics 13 NONCLINICAL TOXICOLOGY Mechanism of action. The analgesic, antipyretic, and anti-inflammatory furnishings of acetylsalicylic acid are due to accomplishments by both the acetyl and the salicylate portions of the complete atom as able-bodied as by the alive salicylate metabolite. This effect inhibits platelet generation of thromboxane A2, resulting in an antithrombotic effect. Acetylsalicylic acid binds to and acetylates serine residues in cyclooxygenases, resulting in decreased synthesis of prostaglandin, platelet aggregation, and inflammation. Theoretical yield: Rev Med Interne. L’acide acétylsalicylique (AAS), plus connu sous le nom commercial d’aspirine, est la substance active de nombreux médicaments aux propriétés antalgiques, antipyrétiques et anti-inflammatoires.Il est aussi utilisé comme antiagrégant plaquettaire. Molecular weight of salicylic acid = 138 g/mole. Keywords:Acetylsalicylic acid, low-molecular-weight heparins, pre-eclampsia, prevention. Acetylsalicylic acid Action. . Silica. The body naturally reduces its heat through perspiration and the dilation (expansion) of blood vessels. Aspirin's recommended therapeutic adult dosage ranges from 600-1,000 mg and works best against "tolerable" pain; extreme pain is virtually unaffected, as is pain in internal organs. Specific inflammatory conditions which aspirin is used to treat include Kawasaki disease, pericarditis, and rheumatic fever. Theoretical yield: Actions Topical keratolytic agent that produces desquamation of the horny layer (stratum corneum) of skin by dissolving the intercellular cement that holds epithelial cells together. This makes aspirin different from other NSAIDs (such as diclofenac and ibuprofen), which are reversible inhibitors. Text. Analgesic, antipyretic and anti-inflammatory agent Non-steroidal anti-inflammatory drug, NSAID Antiplatelet agent: Irreversible cyclo-oxygenase inhibitor

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